Most bipedal rigs tend to have isolation at the head, but a lot of quadrupedal rigs have it at the neck – is it really a case of spreading the isolation from the chest to the head over the length of the neck? This doesn’t seem true of a giraffe – in its case the neck is a column that can be independent of the spine, with secondary bending at its center.
I’ve done both, but am thinking if there’s a commonality between – i.e an approach that can use both.

generally with humanoids I like to isolate @ shoulders and head (but occasionally the neck). Having the ability to isolate translation on head can be handy as well, but always as a switch, not full-time.
my 2c